반응 #7163

반응 방정식

N-(3-ethynylphenyl)-4-hydroxy-3-methoxypheny-acetamide

1-trifluoromethyl-2-iodobenzene

triethylamine

→

desired compound

4-hydroxy-3-methoxy-N-[3-[2-(2-trifluoromethylphenyl)-ethynyl]phenyl]phenylacetamide

용매

acetonitrile

반응 조건

후처리

1. 1
   온도is heated
2. 2
   기타The solvent is evaporated under reduced pressure
3. 3
   기타the residue is purified by silica gel column chromatography (eluent: gradient from 0% to 100% hexane/ethyl acetate)

실험 절차

A mixture of N-(3-ethynylphenyl)-4-hydroxy-3-methoxypheny-acetamide (the compound of Example 19) (200 mg), 1-trifluoromethyl-2-iodobenzene (280 mg), copper (I) iodide (19 mg), bis(triphenylphosphine)palladium (II) dichloride (70 mg), triethylamine (1 g) and acetonitrile (3 ml) is heated with stirring at 50° C. under argon atmosphere for 18 hours. The solvent is evaporated under reduced pressure, and the residue is purified by silica gel column chromatography (eluent: gradient from 0% to 100% hexane/ethyl acetate) to give the desired compound (120 mg).

출처