반응 #7156

반응 방정식

ethyl acetate

6-Nitroindole

benzyl chloride

potassium hydroxide

→

N-benzyl-6-nitroindole

수율 90.0%

용매

dimethylsulfoxide

반응 조건

후처리

1. 1
   세척the organic layer is washed with water
2. 2
   건조dried over sodium sulfate
3. 3
   기타the solvent is evaporated under reduced pressure
4. 4
   기타The residue is purified by silica gel column chromatography (eluent: gradient from 0% to 100% hexane/ethyl acetate)

실험 절차

6-Nitroindole (1.0 g) and benzyl chloride (2.2 g) are dissolved in dimethylsulfoxide (10 ml), and thereto is added potassium hydroxide (1.0 g), and the mixture is stirred at room temperature for 12 hours. To the mixture is added ethyl acetate, and the organic layer is washed with water, dried over sodium sulfate, and the solvent is evaporated under reduced pressure. The residue is purified by silica gel column chromatography (eluent: gradient from 0% to 100% hexane/ethyl acetate) to give N-benzyl-6-nitroindole (1.4 g).

출처