반응 #71511

반응 방정식

Propargyl amine

methyl trifluoroacetate

→

propargyltrifluoroacetamide

수율 87.4%

반응 조건

후처리

1. 1
   농축concentrated under reduced pressure
2. 2
   기타to remove methanol
3. 3
   workup.DISTILLATIONThe product was purified by vacuum distillation

실험 절차

Propargyl amine (4.00 g, 72.62 mmol, 1.00 equiv.) was added dropwise to methyl trifluoroacetate (11.16 g, 87.15 mmol, 1.20 equiv.) at 0° C. The reaction mixture was stirred at 0° C. for 2 h and then concentrated under reduced pressure to remove methanol. The product was purified by vacuum distillation yielding propargyltrifluoroacetamide as a colorless liquid (9.59 g, 87%). The structure was confirmed by 1H- and 19F-NMR.

출처