반응 #71474

반응 방정식

Benzyl chloride

2-nitroimidazole

triethylamine

→

title compound

수율 50.4%

1-Benzyl-2-nitro-1H-imidazole

수율 50.4%

용매

DCM

DCM

반응 조건

후처리

1. 1
   온도at reflux for 72 h
2. 2
   세척washed with H2O and brine
3. 3
   건조dried (sodium sulfate)
4. 4
   여과filtered
5. 5
   농축concentrated
6. 6
   기타The residue was purified by silica gel column chromatography (Hex/EtOAc, 7:3)

실험 절차

Benzyl chloride (1.8 mL, 15.4 mmol, 1.2 equiv) was added to a solution of 2-nitroimidazole (1.45 g, 12.8 mmol) and triethylamine (3.6 mL, 25.7 mmol, 2 equiv) in DCM (40 mL). The reaction mixture was stirred at reflux for 72 h, allowed to cool to rt, diluted with DCM, washed with H2O and brine, dried (sodium sulfate), filtered and concentrated. The residue was purified by silica gel column chromatography (Hex/EtOAc, 7:3) to afford 1.31 g of the title compound as a white solid: ES-MS: 204.0 [M+H]+; tR=3.72 min (System 1); TLC: Rf=0.22 (Hex/EtOAc, 7:3).

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