반응 #714671

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Et3N

2-chloro-5-[(1-methyl-1H-imidazol-5-yl)carbonyl]pyridine

Intermediate 22

2-chloro-5-[(1-methyl-1H-imidazol-5-yl)carbonyl]pyridine

dimethylamine hydrochloride

→

title compound

N,N-Dimethyl-5-[(1-methyl-1H-imidazol-5-yl)carbonyl]pyridin-2-amine

용매

methanol

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후처리

1. 1
   기타In a 50-mL round-bottom flask was placed
2. 2
   농축concentrated under vacuum
3. 3
   기타The residue was purified by flash column chromatography (silica gel column, 100:0-20:1 CH2Cl2/MeOH)

실험 절차

In a 50-mL round-bottom flask was placed a solution of 2-chloro-5-[(1-methyl-1H-imidazol-5-yl)carbonyl]pyridine (250 mg, 1.13 mmol, Intermediate 22, step c), dimethylamine hydrochloride (96 mg, 1.2 mmol), and Et3N (342 mg, 3.39 mmol) in methanol (15 mL). The resulting mixture was heated at 75° C. overnight and concentrated under vacuum. The residue was purified by flash column chromatography (silica gel column, 100:0-20:1 CH2Cl2/MeOH) to give the title compound as a light yellow solid.

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