반응 #71418

반응 방정식

ethyl-2-bromoisobutyrate

ethylene diamine

potassium carbonate

→

title compound

수율 68.8%

3,3-Dimethyl-piperazin-2-one

수율 68.8%

용매

toluene

toluene

반응 조건

후처리

1. 1
   온도cooled
2. 2
   여과filtered
3. 3
   농축The filtrate was concentrated
4. 4
   기타the residue triturated in Et2O

실험 절차

A solution of ethyl-2-bromoisobutyrate (24 mL, 161 mmol) in toluene (150 mL) was added to a mixture of ethylene diamine (70 mL, 1046 mmol, 6.5 equiv) and potassium carbonate (24.4 g, 177 mmol, 1.1 equiv) in toluene (150 mL). The reaction mixture was heated for 20 h at 115° C., cooled and filtered. The filtrate was concentrated and the residue triturated in Et2O to afford 14.2 g of the title compound as a yellow solid: ESI-MS: 129.1 [M+H]+.

출처