반응 #71416

반응 방정식

LiAlH4

4-(4-methoxybenzyl)-3,3-dimethyl-piperazin-2-one

→

title compound

수율 92.3%

1-(4-Methoxy-benzyl)-2,2-dimethyl-piperazine

수율 92.3%

용매

THF

반응 조건

후처리

1. 1
   기타quenched by sequential addition of H2O (1 mL), 1 N NaOH (1 mL) and H2O (3 mL)
2. 2
   여과filtered through a pad of celite
3. 3
   농축concentrated

실험 절차

LiAlH4 (1M in THF, 27.8 mL, 27.8 mmol, 1.5 equiv) was added to a solution of 4-(4-methoxybenzyl)-3,3-dimethyl-piperazin-2-one (Step 108.3) (4.6 g, 18.5 mmol) in THF (100 mL) at 50° C., under an argon atmosphere. The resulting mixture was stirred for 2 h at 50° C., quenched by sequential addition of H2O (1 mL), 1 N NaOH (1 mL) and H2O (3 mL), filtered through a pad of celite and concentrated to afford 4.0 g of the title compound as a white solid: ESI-MS: 235.2 [M+H]+.

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