반응 #71341

반응 방정식

Formaldehyde

diethyl amine

2-nitro-imidazole

→

title compound

Diethyl-(2-nitro-1H-imidazol-4-ylmethyl)-amine

용매

EtOH

반응 조건

후처리

1. 1
   온도The resulting mixture was heated
2. 2
   온도to reflux for 18 h
3. 3
   농축concentrated

실험 절차

Formaldehyde (36% in H2O, 1.0 mL, 13.3 mmol, 1.5 equiv) and diethyl amine (0.92 mL, 8.8 mmol) were added sequentially to a suspension of 2-nitro-imidazole (1 g, 8.8 mmol) in EtOH (20 mL). The resulting mixture was heated to reflux for 18 h, allowed to cool to rt, and concentrated. Trituration of the residue in Et2O afforded an impure sample of the title compound which was used without further purification.

출처