반응 #71333

반응 방정식

4-(4-nitro-phenyl)-piperazine-1-carboxylic acid tert-butyl ester

→

title compound

수율 96.7%

4-(4-Amino-phenyl)-piperazine-1-carboxylic acid tert-butyl ester

수율 96.7%

용매

MeOH

반응 조건

후처리

1. 1
   여과The reaction mixture was filtered through a pad of celite
2. 2
   농축concentrated

실험 절차

A suspension of 4-(4-nitro-phenyl)-piperazine-1-carboxylic acid tert-butyl ester (Step 8.3) (1.26 g, 4.1 mmol) and palladium on carbon (200 mg) in MeOH (30 mL) was stirred for 30 min at rt, under a hydrogen atmosphere. The reaction mixture was filtered through a pad of celite and concentrated to afford 1.1 g of the title compound as a pink solid: ESI-MS: 278.2 [M+H]+; tR=2.85 min (System 1).

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