반응 #7120

반응 방정식

cis-2-Aminocyclohexanecarboxylic acid methyl ester

ammonium hydroxide

→

cis-2-aminocyclohexanecarboxylic acid amide

용매

toluene

반응 조건

후처리

1. 1
   농축The reaction was concentrated to dryness in vacuo
2. 2
   기타azeotroped with toluene (50 mL)
3. 3
   기타The crude product, cis-2-aminocyclohexanecarboxylic acid amide, was used in the next reaction without purification

실험 절차

cis-2-Aminocyclohexanecarboxylic acid methyl ester (2.20 g, 14.0 mmol) was treated with aqueous ammonium hydroxide (40 mL) in toluene (40 mL) and stirred vigorously at room temperature for 16 h. The reaction was concentrated to dryness in vacuo and azeotroped with toluene (50 mL). The crude product, cis-2-aminocyclohexanecarboxylic acid amide, was used in the next reaction without purification: 1H NMR (400 MHz, DMSO-d6) δ 7.78 (2 H, s br), 7.67 (s, 1 H), 7.25 (s, 1 H), 1.87 (m, 2 H), 1.60 (m, 4 H), 1.41 (m, 4 H).

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