반응 #711137

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methanol

2-chloro-5-[(1-methyl-1H-imidazol-5-yl)carbonyl]pyridine

Intermediate 4

2-chloro-5-[(1-methyl-1H-imidazol-5-yl)carbonyl]pyridine

→

title compound

(6-Methoxypyridin-3-yl)(1-methyl-1H-imidazol-5-yl)methanone

반응 조건

후처리

1. 1
   기타In a 50-mL round-bottom flask was placed
2. 2
   농축concentrated under vacuum
3. 3
   기타The residue was purified by flash column chromatography (silica gel, 100:0-20:1 CH2Cl2:MeOH)

실험 절차

In a 50-mL round-bottom flask was placed a solution of Na (260 mg, 11.3 mmol) in methanol (15 mL) and the solution was stirred for 30 minutes at room temperature. Then 2-chloro-5-[(1-methyl-1H-imidazol-5-yl)carbonyl]pyridine (250 mg, 1.13 mmol, Intermediate 4, step c) was added. The resulting mixture was stirred for 4 hours at 75° C. and concentrated under vacuum. The residue was purified by flash column chromatography (silica gel, 100:0-20:1 CH2Cl2:MeOH) to give the title compound as a light yellow solid.

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