반응 #71062

반응 방정식

NaBH4

N2

6-(2-methyl-[1,3]dioxolan-2-yl)-pyridine-2-carbaldehyde

Water

→

title compound

[6-(2-Methyl-[1,3]dioxolan-2-yl)-pyridin-2-yl]-methanol

용매

MeOH

반응 조건

후처리

1. 1
   추출the mixture was extracted with EA
2. 2
   건조extracts were dried over Na2SO4
3. 3
   여과filtered
4. 4
   기타the solvent was removed under reduced pressure

실험 절차

In a flame dried round-bottomed flask equipped with a magnetic stir bar and under inert atmosphere (N2), to a ice-cold solution of 6-(2-methyl-[1,3]dioxolan-2-yl)-pyridine-2-carbaldehyde (713 mg, 3.69 mmol) in MeOH (10.0 mL) was added NaBH4 (180 mg, 4.57 mmol in four equal portions). The reaction mixture was then stirred for 1 h at rt. Water was added and the mixture was extracted with EA followed twice with EA-MeOH 9:1. The combined org. extracts were dried over Na2SO4, filtered, and the solvent was removed under reduced pressure to give the title compound as a pale yellow solid. LC-MS-conditions 02: tR=0.46 min; [M+H]+=196.49.

출처