반응 #710542

반응 방정식

HCl

isobutylamine

4-bromobenzenesulfonyl chloride

pyridine

→

4-bromo-N-isobutyl-benzenesulfonamide

수율 87.3%

용매

DCM

반응 조건

후처리

1. 1
   추출the reaction extracted with DCM
2. 2
   여과filtered through a phase separator
3. 3
   농축concentrated

실험 절차

To a solution of 4-bromobenzenesulfonyl chloride (2 g, 7.8 mmol) in DCM (40 mL) was added pyridine (1.9 mL, 23.5 mmol) followed by isobutylamine (1.56 mL, 15.7 mmol) and the reaction was stirred at room temperature for 16 hours. 1M aqueous HCl was added and the reaction extracted with DCM, filtered through a phase separator and concentrated to give 4-bromo-N-isobutyl-benzenesulfonamide (1.99 g). LCMS (m/z, Method A) ES+ 294[M+1]+

출처