반응 #710538

반응 방정식

methanesulfonyl chloride

4-bromobenzylalcohol

Et3N

→

methanesulfonic acid 4-bromo-benzyl ester

수율 94.0%

용매

DCM

반응 조건

후처리

1. 1
   기타quenched with water
2. 2
   workup.ADDITIONSaturated aqueous NaHCO3 was added
3. 3
   추출the product was extracted with DCM
4. 4
   여과the combined organic extracts were filtered through a phase separator cartridge
5. 5
   농축concentrated

실험 절차

To a solution of 4-bromobenzylalcohol (2 g, 10.7 mmol) in DCM (30 mL) at 0° C. was added Et3N (2.2 mL, 16.0 mmol) followed by methanesulfonyl chloride (910 μL, 11.8 mmol). The reaction was allowed to warm to room temperature, stirred for 2 hours and then quenched with water. Saturated aqueous NaHCO3 was added, the product was extracted with DCM, the combined organic extracts were filtered through a phase separator cartridge and concentrated to give methanesulfonic acid 4-bromo-benzyl ester (2.67 g, 10 mmol, 94%). A solution of the crude product (2.67 g, 10 mmol) in DMSO (40 mL) was stirred at room temperature for 16 hours with potassium thioacetate (1.26 g, 11 mmol). The reaction was treated with water and extracted with DCM, filtered through a phase separator, concentrated and purified by silica gel column chromatography (0-50% DCM in cyclohexane) to give thioacetic acid S-(4-bromo-benzyl) ester (1.81 g, 7.39 mmol, 69%). 1H NMR (300 MHz, CDCl3): δ 7.41 (d, 2 H), 7.16 (d, 2 H), 4.05 (s, 2 H), 2.35 (s, 3 H).

출처