반응 #710503

ord-09beeee2505841458329c4dc2d85ed28

반응 방정식

O=C(O)CC(O)(CC(=O)O)C(=O)O
citric acid
O=C([O-])O.[Na+]
sodium bicarbonate
→
O=C(O)CC(O)(CC(=O)O)C(=O)O.O=C([O-])CC(O)(CC(=O)[O-])C(=O)[O-].[Na+].[Na+].[Na+]
Sodium Citrate Citric Acid

반응물

O=C(O)CC(O)(CC(=O)O)C(=O)O
citric acid
O=C([O-])O.[Na+]
sodium bicarbonate

시약

없음

용매

O
water
O
water

반응 조건

상세 조건
See reaction.notes.procedure_details.

후처리

  1. 1
    기타reaction
  2. 2
    기타for the reaction
  3. 3
    기타Carbon dioxide is evaporated rapidly
  4. 4
    기타water is gradually evaporated
  5. 5
    workup.ADDITIONa mixture of 87% Sodium citrate and 13% citric acid active ingredient
  6. 6
    기타The product is then dried
  7. 7
    기타crushed to fine particles
  8. 8
    기타to produce an active composition suitable for formulation into the pharmacological formulations of this invention

실험 절차

Mix one part citric acid and one part sodium bicarbonate than gradually spray sterile water into the mixture to make reaction. The water is merely the medium for the reaction. Carbon dioxide is evaporated rapidly and water is gradually evaporated. The remaining product is a mixture of 87% Sodium citrate and 13% citric acid active ingredient. The product is in the form of crystals. The product is then dried and crushed to fine particles to produce an active composition suitable for formulation into the pharmacological formulations of this invention.

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US09301935B2uspto-grants-2016_04