반응 #710475

반응 방정식

2-aminopyridine

EDC-HCl

chlorodifluoroacetic acid

→

2-chloro-2,2-difluoro-N-(pyridin-2(1H)-ylidene)acetamide

수율 24.0%

용매

dichloromethane

dichloromethane

반응 조건

후처리

1. 1
   세척washed with water and 1% hydrochloric acid
2. 2
   건조dried over anhydrous magnesium sulfate

실험 절차

200 mg (2.13 mmol) of 2-aminopyridine was dissolved in 5 ml of dichloromethane, 491 mg (2.55 mmol) of EDC-HCl, 311 mg (2.55 mmol) of DMAP and 187 μl (2.23 mmol, 290 mg) of chlorodifluoroacetic acid were added thereto in sequence, and the resulting mixture was stirred overnight. After the reaction was completed, the reaction solution was diluted with dichloromethane, washed with water and 1% hydrochloric acid, and then dried over anhydrous magnesium sulfate to obtain 105 mg (yield 24%) of 2-chloro-2,2-difluoro-N-(pyridin-2(1H)-ylidene)acetamide.

출처