반응 #710467

반응 방정식

2-chloro-3-fluoro-5-methyl pyridine

N-bromosuccinimide

→

5-(bromomethyl)-2-chloro-3-fluoropyridine

수율 51.0%

용매

carbon tetrachloride

반응 조건

후처리

1. 1
   온도the resulting mixture was heated
2. 2
   온도refluxed overnight
3. 3
   기타was returned to room temperature
4. 4
   농축concentrated under reduced pressure
5. 5
   기타purified by silica gel column chromatography (hexane:ethyl acetate=19:1)

실험 절차

4.00 g (27.6 mmol) of 2-chloro-3-fluoro-5-methyl pyridine was dissolved in 80 ml of carbon tetrachloride, 7.37 g (41.4 mmol) of N-bromosuccinimide and 20 mg of benzoyl peroxide were added thereto, and the resulting mixture was heated and refluxed overnight. After the reaction was completed, the reaction solution was returned to room temperature, concentrated under reduced pressure and purified by silica gel column chromatography (hexane:ethyl acetate=19:1) to obtain 3.06 g (yield 51%) of 5-(bromomethyl)-2-chloro-3-fluoropyridine.

출처