반응 #710462

반응 방정식

dimethyl sulfate

2-amino-3-methyl-5-chlorobenzoic acid

potassium carbonate

sodium chloride

→

2-amino-3-methyl-5-chlorobenzoic acid methyl ester

용매

DMF

반응 조건

후처리

1. 1
   기타reacted at 110° C. for 7 hours
2. 2
   온도cooled to room temperature
3. 3
   추출extracted with acetate ethyl
4. 4
   건조dried over anhydrous sodium sulfate
5. 5
   여과filtered
6. 6
   기타the solvent was removed

실험 절차

To a 500 mL round-bottom flask, 0.2 mol of 2-amino-3-methyl-5-chlorobenzoic acid having the structural formula of IV-5, 300 mL of DMF and 2.0 grams of potassium carbonate were added, stirred at room temperature for 0.5 hour, dimethyl sulfate was dripped, reacted at 110° C. for 7 hours, and cooled to room temperature, poured into a saturated sodium chloride solution, extracted with acetate ethyl, dried over anhydrous sodium sulfate, filtered and the solvent was removed to obtain a crude product, 35.2 grams of 2-amino-3-methyl-5-chlorobenzoic acid methyl ester having a structural formula of VIII-3 was obtained by column chromatography, and the yield was 88.4%;

출처