반응 #709877

반응 방정식

4-methoxy-3-methylaniline

hydrochloric acid

hydroxylamine hydrochloride

chloral hydrate

sodium sulphate

sodium sulphate decahydrate

→

N-(4-methoxy-3-methylphenyl)-2-hydroxyiminoacetamide

용매

water

water

water

water

반응 조건

후처리

1. 1
   workup.ADDITIONwas then added
2. 2
   workup.WAITleft at room temperatue overnight
3. 3
   기타The solid product was collected
4. 4
   세척washed with water
5. 5
   기타dried

실험 절차

To a stirred solution of chloral hydrate (123.5 g) in water (1650 ml) was added a solution of anhydrous sodium sulphate (500 g) in water (640 ml) followed by sodium sulphate decahydrate (644 g). A solution of 4-methoxy-3-methylaniline (94 g) in a mixture of concentrated hydrochloric acid (59 ml) and water (400 ml) was then added, followed by a solution of hydroxylamine hydrochloride (151 g) in water (690 ml). The mixture was boiled for 5 minutes and then left at room temperatue overnight. The solid product was collected, washed with water and dried to give the novel compound, N-(4-methoxy-3-methylphenyl)-2-hydroxyiminoacetamide, m.p. 163°-165°.

출처