반응 #709608

반응 방정식

hydrochloric acid

2-(4-carbamoyloxypiperidin-1-yl)-2-iminoethylchloride hydrochloride

trisodium phosphorothioate

→

2-(4-carbamoyloxypiperidin-1-yl)-2-iminoethylmercaptan hydrochloride

수율 97.8%

용매

water

반응 조건

후처리

1. 1
   온도the mixture was heated at 60° C. for 30 minutes

실험 절차

4.95 g of trisodium phosphorothioate were added to an ice-cooled solution of 6.40 g of 2-(4-carbamoyloxypiperidin-1-yl)-2-iminoethylchloride hydrochloride in 32 ml of water, and the mixture was stirred at room temperature for 2.5 hours. 28 ml of 1N hydrochloric acid were then added, and the mixture was heated at 60° C. for 30 minutes. The reaction mixture was worked up in the same manner as in Example 1(2), giving 6.20 g of 2-(4-carbamoyloxypiperidin-1-yl)-2-iminoethylmercaptan hydrochloride.

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