반응 #708953

반응 방정식

myristic acid

carbonyl diimidazole

1-Methyl-piperazine

→

title compound

4-Methyl-1-(1-oxotetradecyl)piperazine

용매

tetrahydrofuran

반응 조건

후처리

1. 1
   기타reacted overnight at ambient temperature
2. 2
   기타The reaction mixture is evaporated under reduced pressure
3. 3
   기타dried in vacuo
4. 4
   기타purified on a column of silica gel in the system CH2Cl2 :CH3OH (5:1)
5. 5
   기타evaporated under reduced pressure (<30°)
6. 6
   기타dried in vacuo

실험 절차

680 mg (3 meq) of myristic acid and 486 mg (3 meq) of carbonyl diimidazole are reacted in a minimum volume of tetrahydrofuran at ambient temperature for 1.5 hours. 1-Methyl-piperazine (0.33 ml, 3 meq) is added and reacted overnight at ambient temperature. The reaction mixture is evaporated under reduced pressure, dried in vacuo and purified on a column of silica gel in the system CH2Cl2 :CH3OH (5:1). The fractions having Rf 0.80 on TLC silica gel CH2Cl2 :CH3OH (5:1)-iodine are combined, evaporated under reduced pressure (<30°) and dried in vacuo to yield 85 mg of title compound.

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