반응 #708952

반응 방정식

myristic acid

carbonyl diimidazole

Unsym-dimethylhydrazine

→

title compound

Tetradecanoic acid 2,2-dimethylhydrazide

용매

tetrahydrofuran

반응 조건

후처리

1. 1
   기타reacted overnight at room temperature
2. 2
   기타The reaction mixture is evaporated under reduced pressure
3. 3
   기타dried in vacuo
4. 4
   기타purified on a silica gel column
5. 5
   기타evaporated under reduced pressure
6. 6
   기타dried in vacuo

실험 절차

690 mg (3 meq) of myristic acid and 486 mg (3 meq) of carbonyl diimidazole are reacted in a minimum volume of tetrahydrofuran at room temperature for 1 hour. Unsym-dimethylhydrazine (0.23 ml, 3 meq) is added and reacted overnight at room temperature. The reaction mixture is evaporated under reduced pressure, dried in vacuo and purified on a silica gel column using CH2Cl2 :CH3OH (5:1). The fractions having R6 0.76 on TLC S.G. CH2Cl2 :CH3OH (5:1) chlorine-peptide spray are combined, evaporated under reduced pressure and dried in vacuo to yield 185 mg of title compound having a m.p. of 63.5°-64.5° C.

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