반응 #708778

반응 방정식

fumaric acid

Potassium carbonate

4,5-dihydro-N-(4-hydroxyphenyl)-1-phenyl-1H-pyrazol-3-amine

2-diethylaminoethylchloride hydrochloride

→

title compound

N-[4-(2-diethylaminoethoxy)phenyl]-4,5-dihydro-1-phenyl-1H-pyrazol-3-amine 2E-butenedioate

용매

ether

water

ether

dimethylformamide

반응 조건

후처리

1. 1
   추출extracted with ethyl acetate
2. 2
   세척The combined extracts were washed with water
3. 3
   기타dried
4. 4
   기타Solvent was removed
5. 5
   기타to give an oil which
6. 6
   기타to give a precipitate
7. 7
   기타This was collected
8. 8
   기타dried

실험 절차

Potassium carbonate (6.92 g), 4,5-dihydro-N-(4-hydroxyphenyl)-1-phenyl-1H-pyrazol-3-amine (4.22 g) and 2-diethylaminoethylchloride hydrochloride (2.95 g) in dimethylformamide (30 ml) were stirred together at room temperature for 25 hours. The reaction mixture was then diluted with water and extracted with ethyl acetate. The combined extracts were washed with water and dried. Solvent was removed to give an oil which was redissolved in ether and a solution of fumaric acid (0.33 g) in ether added to give a precipitate. This was collected and dried to give the title compound, (4.2 g) mp 54°-56° (dec).

출처