반응 #70699

반응 방정식

DEAD

6-hydroxy-1-isopropyl-1H-indole-4-carboxylic acid methyl ester

2-dimethylamino-ethanol

PPh3

→

title compound

수율 60.2%

6-(2-Dimethylamino-ethoxy)-1-isopropyl-1H-indole-4-carboxylic acid methyl ester

수율 60.2%

용매

THF

반응 조건

후처리

1. 1
   온도To a cooled
2. 2
   기타Reaction mixture
3. 3
   농축was concentrated under reduced pressure
4. 4
   기타the residue was purified by column chromatography
5. 5
   세척by eluting with 2% MeOH in chloroform

실험 절차

To a cooled (0° C.) mixture of 6-hydroxy-1-isopropyl-1H-indole-4-carboxylic acid methyl ester (700 mg, 3 mmol), 2-dimethylamino-ethanol (320 mg, 3.60 mmol) and PPh3 (948 mg, 3.60 mmol) in THF (10 mL) was added DEAD (620 mg, 3.60 mmol) and stirred for 16 h at RT. Reaction mixture was concentrated under reduced pressure and the residue was purified by column chromatography by eluting with 2% MeOH in chloroform to afford the title compound (550 mg, 60%) as colorless gum. LCMS (ES+): m/z=305.36 [M+H].

출처