반응 #70640

반응 방정식

N-tert-butyl-5-cyano-2-fluoro-benzenesulfonamide

→

5-aminomethyl-N-tert-butyl-2-fluoro-benzenesulfonamide

수율 90.0%

용매

HCl EtOH

반응 조건

후처리

1. 1
   여과The reaction mixture was filtered through a pad of diatomaceous earth
2. 2
   세척washed with MeOH
3. 3
   농축concentrated to about 3 ml
4. 4
   workup.ADDITIONThe residue was diluted with H2O

실험 절차

A mixture of N-tert-butyl-5-cyano-2-fluoro-benzenesulfonamide (0.3 g) and Pd/C (50 mg) in 1N HCl/EtOH (1 ml 1N HCl in 10 ml EtOH) was stirred under H2 for 2 hours. The reaction mixture was filtered through a pad of diatomaceous earth, washed with MeOH and concentrated to about 3 ml. The residue was diluted with H2O and lyophilized to give 5-aminomethyl-N-tert-butyl-2-fluoro-benzenesulfonamide (0.27 g, 90% yield) as a white powder.

출처