반응 #70638

반응 방정식

Tert-butyl 1-(trifluoromethyl)cyclopropylcarbamate

HCl

→

1-(trifluoromethyl)cyclopropylamine hydrochloride

수율 91.0%

반응 조건

후처리

1. 1
   온도at reflux for 3.5 h
2. 2
   농축The solution was concentrated in vacuo
3. 3
   기타the residue was triturated with acetone
4. 4
   기타The filtrate was collected
5. 5
   농축concentrated
6. 6
   기타the residue triturated with diethyl ether

실험 절차

Tert-butyl 1-(trifluoromethyl)cyclopropylcarbamate (4.08 g, 18.3 mmol) was suspended in 1 N HCl(aq) (150 mL) and stirred at reflux for 3.5 h. The solution was concentrated in vacuo and the residue was triturated with acetone. The filtrate was collected, concentrated, and the residue triturated with diethyl ether to afford 2.67 g (91%) of 1-(trifluoromethyl)cyclopropylamine hydrochloride as a white solid.

출처