반응 #706328

반응 방정식

allyl bromide

ethyl salicylate

K2CO3

→

ethyl 2-(2-propenyloxy)benzoate

수율 98.3%

용매

DMF

반응 조건

후처리

1. 1
   온도The reaction mixture was then heated on a steam bath for 2 hours
2. 2
   기타the K2CO3 was removed by filtration
3. 3
   workup.ADDITIONthe reaction mixture was poured into water
4. 4
   추출extracted with ethyl acetate (3×300 ml)
5. 5
   세척The organic layer was washed with brine
6. 6
   건조dried over MgSO4
7. 7
   기타the solvent was removed

실험 절차

To a solution of ethyl salicylate (100 g, 0.602 mol) in DMF (400 ml) was added K2CO3 (150 g), followed by the dropwise addition of allyl bromide (87.5 g, 0.723 mol). The reaction mixture was then heated on a steam bath for 2 hours, the K2CO3 was removed by filtration and the reaction mixture was poured into water and extracted with ethyl acetate (3×300 ml). The organic layer was washed with brine, and dried over MgSO4, and the solvent was removed to afford 122 g (98%) of ethyl 2-(2-propenyloxy)benzoate.

출처