반응 #70618

반응 방정식

N-tert-butyl-4-cyano-3-methylbenzenesulfonamide

HCl

→

4-(aminomethyl)-N-tert-butyl-3-methylbenzenesulfonamide

수율 113.5%

용매

HCl EtOH

반응 조건

후처리

1. 1
   workup.STIRRINGwas stirred overnight
2. 2
   여과The reaction mixture was filtered through a pad of diatomaceous earth
3. 3
   세척washed with MeOH
4. 4
   농축concentrated to about 3 ml
5. 5
   workup.ADDITIONThe residue was diluted with H2O

실험 절차

The reaction mixture of N-tert-butyl-4-cyano-3-methylbenzenesulfonamide (0.7176 g) and Pd/C (0.97 g) in 1N HCl/EtOH (1.5 ml 1N HCl in 15 ml EtOH) was stirred under H2 for 2 hours. Then 1N HCl (3 ml) was added to improve the reaction progress and it was stirred overnight. The reaction mixture was filtered through a pad of diatomaceous earth, washed with MeOH and concentrated to about 3 ml. The residue was diluted with H2O and lyophilized to give 0.8275 g 4-(aminomethyl)-N-tert-butyl-3-methylbenzenesulfonamide as white powder.

출처