반응 #70570

반응 방정식

ethyl 1-benzylpiperidine-4-carboxylate

sodium hydroxide

→

title intermediate

sodium 1-benzylpiperidine-4-carboxylate

용매

ethanol

반응 조건

후처리

1. 1
   기타Most of the ethanol was removed under reduced pressure
2. 2
   workup.STIRRINGstirring
3. 3
   workup.WAITwas continued for six hours
4. 4
   workup.ADDITIONToluene was added
5. 5
   기타to remove most of the water by azeotrope
6. 6
   기타the material was dried under high vacuum overnight

실험 절차

To a solution consisting of ethyl 1-benzylpiperidine-4-carboxylate (500 mg, 2.02 mmol) in ethanol (10 mL) was added 1 N sodium hydroxide (2.02 mL, 2.02 mmol) and the reaction mixture was stirred at room temperature overnight. Most of the ethanol was removed under reduced pressure and stirring was continued for six hours. Toluene was added to remove most of the water by azeotrope and the material was dried under high vacuum overnight to provide the title intermediate as a white solid.

출처