반응 #70512

반응 방정식

3-[4-(1H-Indol-3-yl)-piperidine-1-carbonyl]-benzonitrile

NaOH

tetrabutyl ammonium hydroxide

4-fluoro-benzyl bromide

→

3-{4-[1-(4-Fluoro-benzyl)-1H-indol-3-yl]-piperidine-1-carbonyl}-benzonitrile

용매

THF

반응 조건

후처리

1. 1
   기타The layers are separated
2. 2
   기타the organic solvent is removed under the reduced pressure
3. 3
   기타purified by a silica gel flash column

실험 절차

3-[4-(1H-Indol-3-yl)-piperidine-1-carbonyl]-benzonitrile (0.08 g, 0.24 mmol) is dissolved in 2 ml THF, then 2 ml of 50% NaOH, 0.2 ml tetrabutyl ammonium hydroxide (1.0M in MeOH), 4-fluoro-benzyl bromide (0.055 g, 0.29 mmol) are added and the reaction mixture is stirred at RT for 1.5 hours. The layers are separated and the organic solvent is removed under the reduced pressure, purified by a silica gel flash column using heptane and ethyl acetate as the elutes.

출처