반응 #70494

반응 방정식

6-[4-(4-Benzyl-phthalazin-1-yl)-piperazin-1-yl]-pyridin-3-ylamine

triethylamine

dimethylcarbamoyl chloride

→

title compound

수율 68.0%

3-{6-[4-(4-Benzyl-phthalazin-1-yl)-piperazin-1-yl]-pyridin-3-yl}-1,1-dimethyl-urea

수율 68.0%

용매

CH2Cl2

반응 조건

후처리

1. 1
   농축Concentrate the crude
2. 2
   기타reaction mixture in vacuo
3. 3
   기타The residue is purified by flash chromatography on silica gel (MeOH/CH2Cl2)

실험 절차

6-[4-(4-Benzyl-phthalazin-1-yl)-piperazin-1-yl]-pyridin-3-ylamine (80 mg, 0.202 mmol), CH2Cl2 (0.5 mL), triethylamine (37 μL, 0.227 mmol), and dimethylcarbamoyl chloride (20 μL, 0.222 mmol) are combined and stirred at room temperature for 16 h. Concentrate the crude reaction mixture in vacuo. The residue is purified by flash chromatography on silica gel (MeOH/CH2Cl2) to afford the title compound (64 mg, 68%).

출처