반응 #70482

반응 방정식

6-piperazin-1-yl-nicotinic acid ethyl ester

1,4-dichlorophthalazine

triethylamine

NMP

→

title compound

수율 49.0%

6-[4-(4-Chloro-phthalazin-1-yl)-piperazin-1-yl]-nicotinic acid ethyl ester

수율 49.0%

용매

H2O

반응 조건

후처리

1. 1
   추출extract organics with EtOAc (3×50 mL)
2. 2
   건조Combined organic layers are dried over MgSO4
3. 3
   농축concentrated
4. 4
   기타Resulting solid
5. 5
   기타is triturated with EtOAc

실험 절차

Combine 6-piperazin-1-yl-nicotinic acid ethyl ester (1.30 g, 5.40 mmol), 1,4-dichlorophthalazine (932 mg, 4.59 mmol), triethylamine (1.78 mL, 13.50 mmol), and NMP (8 mL) and heat to 85° C. for 6 h. Cool to room temperature, dilute with H2O (50 mL) and extract organics with EtOAc (3×50 mL). Combined organic layers are dried over MgSO4 and concentrated. Resulting solid is triturated with EtOAc to give the title compound as a fine tan powder (895 mg, 49% yield).

출처