반응 #70447

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tert-butyl 4-[3-chloro-2-(4-methanesulfonylphenoxymethyl)pyridin-5-yl]-3,6-dihydro-2H-pyridine-1-carboxylate

tert-Butyl 4-[3-chloro-2-(4-methanesulfonylphenoxy-methyl)pyridin-5-yl]-3,6-dihydro-2H-pyridine-1-carboxylate

→

title compound

수율 26.0%

tert-Butyl 4-[3-chloro-2-(4-methanesulfonylphenoxymethyl)pyridin-5-yl]piperidine-1-carboxylate

수율 26.0%

용매

ethyl acetate

반응 조건

후처리

1. 1
   여과filtered through Celite pad
2. 2
   농축The filtrate was concentrated under reduced pressure
3. 3
   기타The residue was purified by silica gel column chromatography (hexane/ethyl acetate=1/1)

실험 절차

To a solution of tert-butyl 4-[3-chloro-2-(4-methanesulfonylphenoxymethyl)pyridin-5-yl]-3,6-dihydro-2H-pyridine-1-carboxylate (Example 70) (50 mg, 0.104 mmol) in ethyl acetate (1 mL) was added platinum oxide (5 mg). The mixture was hydrogenated at room temperature for 4 hours and filtered through Celite pad. The filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (hexane/ethyl acetate=1/1) to give the title compound as a white amorphous (13 mg, yield 26%).

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