반응 #7044

반응 방정식

1,1-di-indol-3-yl-butane

benzylchloride

→

product

수율 78.0%

1,1-di-(N-benzyl-indol-3-yl)-butane

수율 78.0%

용매

H2O CHCl3

반응 조건

후처리

1. 1
   기타The mixture thus obtained
2. 2
   workup.STIRRINGthe ultrasonic stirring
3. 3
   기타the chloroform phase was separated
4. 4
   세척washed with a small amount of water
5. 5
   기타dried on Na2SO4
6. 6
   여과filtered
7. 7
   농축concentrated to dryness
8. 8
   기타The end product was isolated
9. 9
   기타purified chromatographically on silica gel
10. 10
    세척eluting with hexane

실험 절차

ST 1385 1,1-di-indol-3-yl-butane, 290 mg (1 mmol), was thoroughly mixed and blended with potassium tertbutylate (280 mg) and tetrabutylammonium bromide (20 mg). The mixture thus obtained was held under ultrasonic stirring at ambient temperature. 640 mg (5 mmol) of benzylchloride at 0° C. were then added and the ultrasonic stirring was continued for 2 hours at room temperature. At the end of this period, the reaction mixture was treated with H2O/CHCl3; the chloroform phase was separated, washed with a small amount of water, dried on Na2SO4, filtered and concentrated to dryness. The end product was isolated and purified chromatographically on silica gel, eluting with hexane:ethyl ether 95:5.351 mg of product were obtained with a 78% yield.

출처