반응 #7038

반응 방정식

5-fluoroindole

butyraldehyde

→

1,1-di-(5-fluoroindol-3-yl)-butane

수율 45.0%

반응 조건

후처리

1. 1
   기타This was prepared in the same way
2. 2
   기타The reaction
3. 3
   온도however, was heated
4. 4
   온도under reflux for 24 hours
5. 5
   기타The end product was isolated
6. 6
   기타purified by chromatography on an SiO2 column

실험 절차

This was prepared in the same way as described in example 2/2 starting from 5-fluoroindole and butyraldehyde. The reaction, however, was heated under reflux for 24 hours. The end product was isolated and purified by chromatography on an SiO2 column using a hexane:ethyl ether gradient ranging from 7:3 to 4:6 as the eluent. Yield 45%.

출처