반응 #70349

반응 방정식

residue

Ethyl 2-(6-(2-fluoro-5-methoxyphenyl)-5-methylpyridin-3-ylamino)-5-methylbenzoate

NaOH

→

expected product

수율 67.0%

2-(6-(2-Fluoro-5-methoxyphenyl)-5-methylpyridin-3-ylamino)-5-methylbenzoic acid

수율 67.0%

용매

ethanol

water

MeOH NH3

반응 조건

후처리

1. 1
   기타the solvent was evaporated
2. 2
   기타the solid obtained
3. 3
   추출extracted with CHCl3
4. 4
   기타The crude mixture was purified over a SCX cartridge

실험 절차

The solid residue obtained in step A was dissolved in 2 ml of ethanol and 0.150 ml of aqueous solution 2N NaOH were added. The mixture was heated at 60° C. for 2 hours, the solvent was evaporated and the solid obtained was suspended in water. The pH was taken to 6.5 and extracted with CHCl3. The crude mixture was purified over a SCX cartridge eluting with MeOH/NH3 10:1 affording 0.030 g (yield 67%) of the expected product.

출처