반응 #70315

반응 방정식

methyl 2-amino-5-bromobenzoate

cyclopropylboronic acid

K3PO4

P(Cy)3

→

expected product

수율 88.3%

Methyl 2-amino-5-cyclopropylbenzoate

수율 88.3%

용매

toluene

water

반응 조건

후처리

1. 1
   여과The reaction mixture was filtered through celite
2. 2
   기타the organic phase was separated
3. 3
   기타evaporated

실험 절차

In a schlenck tube, a mixture of methyl 2-amino-5-bromobenzoate (43.47 mmol, 10 g), cyclopropylboronic acid (112.92 mmol, 9.700 g), K3PO4 (144.16 mmol, 30.6 g), Pd (AcO)2 (3.47 mmol, 0.780 g), P(Cy)3 (7.85 mmol, 2.2 g) in toluene (170 ml) and water (10 ml) was heated for 2 hours at 100° C., under nitrogen atmosphere. The reaction mixture was filtered through celite and the organic phase was separated and evaporated affording 7.34 g (yield 77%) of the expected product.

출처