반응 #702832

반응 방정식

sodium carbonate

( A )

1-(2,2-diethoxyethyl)-5-amino-3-methylpyrazole

sulfuric acid

→

6-methylimidazo[1,2-b]pyrazole

수율 41.0%

용매

ethanol

반응 조건

후처리

1. 1
   온도under reflux for 5 hours
2. 2
   온도After cooling
3. 3
   여과The resulting mixture was filtered
4. 4
   기타the solvent was removed from the filtrate
5. 5
   기타The thus obtained residue was recrystallized

실험 절차

The resultant (A) was heated in a mixture of 200 ml of ethanol and 80 ml of a 20% aqueous solution of sulfuric acid under reflux for 5 hours. After cooling, excess solid sodium carbonate was added thereto. The resulting mixture was filtered, and the solvent was removed from the filtrate. The thus obtained residue was recrystallized to provide 1.4 g of 6-methylimidazo[1,2-b]pyrazole. Yield was 41%.

출처