반응 #70272

반응 방정식

3-bromo-5-nitropyridin-2-ol

POBr3

PBr3

→

expected product

수율 73.0%

2,3-dibromo-5-nitropyridine

수율 73.0%

용매

water

반응 조건

후처리

1. 1
   추출extracted with DCM
2. 2
   기타The crude mixture was purified by flash chromatography over SiO2 eluting with hexane/ethyl acetate

실험 절차

A mixture of 3-bromo-5-nitropyridin-2-ol, POBr3 and PBr3 was heated at 120° C. for 3.5 h. The crude mixture was poured into a mixture of ice and water and extracted with DCM. The crude mixture was purified by flash chromatography over SiO2 eluting with hexane/ethyl acetate mixtures affording 2.63 g (yield 73%) of the expected product.

출처