반응 #702667

반응 방정식

ethyl salicylate

stearoyl chloride

triethylamine

→

title product

수율 95.2%

Ethyl 2-(octadecanoyloxy)benzoate

수율 95.2%

용매

tetrahydrofuran

반응 조건

후처리

1. 1
   온도After refluxing for 20 hours
2. 2
   기타Most of the tetrahydrofuran was removed with a N2 stream during the cooling process
3. 3
   workup.ADDITIONThe residue was poured into ice/water (1500 ml)
4. 4
   기타a white solid removed by filtration
5. 5
   세척Washing the solid with water
6. 6
   기타drying

실험 절차

To a cold (+5° C.) solution of ethyl salicylate (0.136 moles) and stearoyl chloride (0.136 moles) in tetrahydrofuran (200 ml) was added triethylamine (0.136 moles) dropwise over 25 min. After refluxing for 20 hours, the solution was cooled to room temperature. Most of the tetrahydrofuran was removed with a N2 stream during the cooling process. The residue was poured into ice/water (1500 ml), stirred for 1 hour, and a white solid removed by filtration. Washing the solid with water, followed by air drying gave 56 g of the title product, m.p. 50.5°-53.5° C.

출처