반응 #70254

반응 방정식

2-chloro-5-nitro-3-(trifluoromethyl)pyridine

→

expected product

수율 92.1%

6-Chloro-5-(trifluoromethyl)pyridin-3-amine

수율 92.1%

용매

ethyl acetate

반응 조건

후처리

1. 1
   여과The catalyst was filtered off
2. 2
   세척the solid was washed with warmed ethanol
3. 3
   기타The solvent was evaporated

실험 절차

A mixture of 2-chloro-5-nitro-3-(trifluoromethyl)pyridine (5.25 mmol, 1.19 g), ZnBr2 (1.05 mmol, 0.200 g) and 5% Pt (C) (1.58 mmol, 0.31 g) in ethyl acetate (50 ml) was stirred for 20 hours under hydrogen atmosphere. The catalyst was filtered off and the solid was washed with warmed ethanol. The solvent was evaporated affording the expected product (0.95 g, yield 92%).

출처