반응 #70232

반응 방정식

(E)-6,7-dimethoxy-3,4-dihydronaphthalen-1(2H)-one O-4-nitrobenzyl oxime

ethyl acetate hexane

6-Hydroxy-5-methoxy-1-indanone

pyridine

→

title compound

수율 9.0%

(E)-6-Hydroxy-5-methoxy-2,3-dihydro-1H-inden-1-one O-benzo[c][1,2,5]oxadiazol-5-ylmethyl oxime

수율 9.0%

용매

ethanol

반응 조건

실험 절차

6-Hydroxy-5-methoxy-1-indanone (76 mg, 0.43 mmol) was subjected to reaction with 0-(benzo[c][1,2,5]oxadiazol-5-ylmethyl)hydroxylamine hydrochloride (97 mg, 0.48 mmol) in ethanol (2 mL) and pyridine (0.2 mL, 2.58 mmol) under the same conditions as described for (E)-6,7-dimethoxy-3,4-dihydronaphthalen-1(2H)-one O-4-nitrobenzyl oxime. Subjection of the material obtained on work up to flash chromatography (3:7 v/v ethyl acetate/hexane elution) afforded the title compound as off-white crystals (13 mg, 9%), m.p. 145° C. (with decomposition), Rf 0.3.

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