반응 #702029

반응 방정식

potassium 3-pyridinolate

2-amino 5-iodopyridine

→

2-amino-5-(3-pyridyloxy) pyridine

용매

dimethylacetamide

반응 조건

후처리

1. 1
   온도at reflux under a nitrogen atmosphere for 24 hours
2. 2
   기타The solvent is removed in vacuo
3. 3
   추출the residue is extracted with chloroform
4. 4
   세척Chromatography of the methylene chloride soluble portion with silica gel and elution with ethyl acetate

실험 절차

3.3 G. of potassium 3-pyridinolate, 5.47 g. of 2-amino 5-iodopyridine and 1.78 g. of cuprous oxide in 150 ml. of dimethylacetamide are heated at reflux under a nitrogen atmosphere for 24 hours. The solvent is removed in vacuo and the residue is extracted with chloroform. Chromatography of the methylene chloride soluble portion with silica gel and elution with ethyl acetate yields 2-amino-5-(3-pyridyloxy) pyridine.

출처