반응 #70189

반응 방정식

hydrochloric acid

2-Methyl-4-(1-methyl-cyclopropyl)-benzoic acid methyl ester

methanol

sodium hydroxide

→

2-Methyl-4-(1-methyl-cyclopropyl)-benzoic acid

수율 85.1%

용매

water

반응 조건

후처리

1. 1
   농축The reaction mixture was concentrated until methanol
2. 2
   기타was evaporated
3. 3
   기타A white solid was obtained
4. 4
   온도under heating
5. 5
   온도then cooled with an ice bath
6. 6
   기타A white precipitate was formed
7. 7
   여과filtered
8. 8
   세척washed with water
9. 9
   기타dried under high vacuum over night

실험 절차

2-Methyl-4-(1-methyl-cyclopropyl)-benzoic acid methyl ester (2.75 g, 13.46 mmol) was treated with methanol and 5 M aqueous sodium hydroxide solution (20.46 ml, 102.32 mmol). This solution was heated to 80° C. for 4 hours. The reaction mixture was concentrated until methanol was evaporated. A white solid was obtained. The solid was dissolved in 50 ml water under heating then cooled with an ice bath; acidified with 10 ml conc. hydrochloric acid. A white precipitate was formed; filtered; washed with water; dried under high vacuum over night to yield 2-Methyl-4-(1-methyl-cyclopropyl)-benzoic acid (2.18 g, 11.46 mmol) MS (ESI) 189.1 (M−H)−

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