반응 #701545

반응 방정식

1-[2-hydroxy-3-(2-methoxyphenyloxy)-propyl]-piperidine-4-one

N-(2-aminoethyl)-aniline

hydrogen

→

1-[2-hydroxy-3-(2-methoxyphenyloxy)-propyl]-4-(2-anilino-ethylamino)-piperidine

용매

methanol

반응 조건

후처리

1. 1
   기타The catalyst is thereafter removed by filtration
2. 2
   농축the filtrate is concentrated under reduced pressure
3. 3
   기타The residue is freed from excess starting material in a bulb tube at 0.3 mm Hg and 120° C oven temperature

실험 절차

A solution of 16.7 g of 1-[2-hydroxy-3-(2-methoxyphenyloxy)-propyl]-piperidine-4-one and 10.5 g of N-(2-aminoethyl)-aniline in 250 ml of methanol, with the addition of 1 g of a 5% platinum on charcoal catalyst is hydrogenated at room temperature and under normal pressure until 1 molar equivalent of hydrogen has been taken up. The catalyst is thereafter removed by filtration and the filtrate is concentrated under reduced pressure. The residue is freed from excess starting material in a bulb tube at 0.3 mm Hg and 120° C oven temperature to yield as distillation residue 1-[2-hydroxy-3-(2-methoxyphenyloxy)-propyl]-4-(2-anilino-ethylamino)-piperidine, which can be used without further purification.

출처