반응 #70140

반응 방정식

bupivacaine HCl

glycerin

→

bupivacaine

용매

water

반응 조건

후처리

1. 1
   workup.DISSOLUTIONdissolving
2. 2
   workup.ADDITIONmixing
3. 3
   workup.ADDITIONmixed
4. 4
   workup.ADDITION20 g of granular gelatin is then added
5. 5
   온도the composition heated carefully on a steam bath until the gelatin
6. 6
   workup.DISSOLUTIONis dissolved
7. 7
   workup.ADDITIONThe melted mixture is poured
8. 8
   온도into chilled molds

실험 절차

A composition suitable for administration in vaginal suppository form 1a prepared by weighing 2 mg of finely divided polynucleotide medicinal substance into a tared container, adding 10 ml of 0.5% bupivacaine HCl in purified water, to make a total of 10 g, and dissolving or mixing depending on the solubility of the medicinal substance; 70 g of glycerin is added and mixed; 20 g of granular gelatin is then added and the composition heated carefully on a steam bath until the gelatin is dissolved. The melted mixture is poured into chilled molds to yield 20 vaginal suppositories of 6 grams each containing 100 mcg of polynucleotide medicinal substance in admixture with 2.5 mg bupivacaine.

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