반응 #700718

반응 방정식

1,4-dihydro-8-nitro-4-oxoquinoline

1,3,5-trioxane

hydrochloric acid

→

3-chloromethyl-1,4-dihydro-8-nitro-4-oxoquinoline

용매

dioxane

반응 조건

후처리

1. 1
   기타to stand to ambient temperature
2. 2
   workup.STIRRINGthe mixture was stirred for 1 hour
3. 3
   기타The resulting precipitates
4. 4
   여과were collected by filtration
5. 5
   세척washed with cold water

실험 절차

A mixture of 1,4-dihydro-8-nitro-4-oxoquinoline (10 g) and 1,3,5-trioxane (23.7 g) in dioxane (100 ml) and conc. hydrochloric acid (200 ml) was stirred for 3.5 hours at 90° C. and allowed to stand to ambient temperature. To the mixture was added ice water (700 g), and the mixture was stirred for 1 hour. The resulting precipitates were collected by filtration and washed with cold water to give 3-chloromethyl-1,4-dihydro-8-nitro-4-oxoquinoline (6.5 g).

출처