반응 #700539

반응 방정식

3-benzyloxy-1-propanol

Jones reagent

Ethyl acetate

→

3-benzyloxypropionic acid

용매

acetone

반응 조건

후처리

1. 1
   온도while cooling on ice
2. 2
   세척the resultant mixture was washed with water
3. 3
   추출The organic layer was extracted with a sat. aq. K2CO3
4. 4
   세척the aqueous layer was washed with ethyl acetate
5. 5
   추출again extracted with ethyl acetate
6. 6
   세척washed with saturated brine
7. 7
   건조Drying over anhydrous magnesium sulfate
8. 8
   농축concentrating under reduced pressure

실험 절차

To 3-benzyloxy-1-propanol (1.66 g) dissolved in acetone (10 ml) was added 2N Jones reagent (10 ml) while cooling on ice, and the mixture was stirred for 4 hours at room temperature. Ethyl acetate was added, and the resultant mixture was washed with water. The organic layer was extracted with a sat. aq. K2CO3, and the aqueous layer was washed with ethyl acetate. The washed material was acidified with dilute HCl, again extracted with ethyl acetate, then washed with saturated brine. Drying over anhydrous magnesium sulfate and concentrating under reduced pressure yielded 1.27 g of 3-benzyloxypropionic acid as a colorless crystals.

출처