반응 #6996

반응 방정식

2-(3,4-dichloro-phenoxy)-5-fluorobenzaldehyde

Jones reagent

→

2-(3,4-dichlorophenoxy)-5-fluoro-benzoic acid

용매

acetone

반응 조건

후처리

1. 1
   기타the reaction was quenched with 8 mL of isopropanol
2. 2
   여과filtered through a pad of d.e
3. 3
   농축The filtrate was concentrated in vacuo to approximately ¼ volume
4. 4
   workup.ADDITIONdiluted with water
5. 5
   추출extracted several times with CHCl3
6. 6
   세척The organic layers were washed with water
7. 7
   건조with saturated NaCl and finally dried over MgSO4
8. 8
   농축concentrated

실험 절차

Alternatively, a solution of 4.28 g (15 mmol) of 2-(3,4-dichloro-phenoxy)-5-fluorobenzaldehyde (Preparation no. 5) in 25 mL of acetone was cooled to 5–10° C. and treated via syringe with 5.8 mL (15.6 mmol) of 2.67 M Jones reagent*. After 1 hr at this temperature, the reaction was quenched with 8 mL of isopropanol, allowed to warm to 25° C., and filtered through a pad of d.e. The filtrate was concentrated in vacuo to approximately ¼ volume, diluted with water and extracted several times with CHCl3. The organic layers were washed with water, then with saturated NaCl and finally dried over MgSO4 and concentrated to provide 2-(3,4-dichlorophenoxy)-5-fluoro-benzoic acid as a tan solid, 4.19 g. 1H-nmr (CDCl3, 400 MHz, δ): 7.78 (dd, 1H), 7.38 (d, 1H), 7.27 (m, 1H), 6.98 (m, 2H), 6.81 (dd, 1H). *Jones reagent was prepared from 13.4 g of chromium trioxide and 11.5 mL of concentrated H2SO4, diluted to a final volume of 50 mL with H2O.

출처