반응 #699586

반응 방정식

3-methoxy-1-(3-methoxyphenyl)-2-oxo-4-propionyl-1,2,5,6-tetrahydro-pyridine

cyclopentylhydrazine hydrochloride

sodium methoxide

→

1-cyclopentyl-3-ethyl-6(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1-H-pyrazolo[3,4-c]pyridine

용매

ethanol

반응 조건

후처리

1. 1
   온도was heated to reflux
2. 2
   농축the mixture was concentrated under reduced pressure
3. 3
   기타chromatographed on a silica gel column
4. 4
   기타to give a white solid
5. 5
   기타Recrystallization from ether
6. 6
   기타gave white needles

실험 절차

A stirred mixture of 3-methoxy-1-(3-methoxyphenyl)-2-oxo-4-propionyl-1,2,5,6-tetrahydro-pyridine (0.49 grams, 1.7 mmole), cyclopentylhydrazine hydrochloride (0.40 grams) and sodium methoxide (46 mg, 0.85 mmole) in anhydrous ethanol was heated to reflux. After 16 hours, the mixture was concentrated under reduced pressure and chromatographed on a silica gel column using 1:4 ethyl acetate/hexane as eluent to give a white solid. Recrystallization from ether gave white needles. M.P. 64.65° C.; MS m/z [M+] 340.2025; HRMS [M+] 340.2046.

출처